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Implements code changes and creates commits. Triggered when: implementation tasks, code changes, feature additions, bug fixes.

Create clever, non-offensive trash talk. Rivalry-specific references, historical callbacks, memes. Fun, not mean.

Consensus cell type annotation: runs 10+ algorithms (KNN-Harmony/BBKNN/Scanorama/scVI, CellTypist, ONCLASS, Random Forest, SCANVI, SVM, XGBoost) on a labeled reference and transfers labels via majority voting. Outputs per-method labels, consensus, agreement score. Use when single-method annotation is insufficient or you need ensemble uncertainty for novel states.

Creates Claude Code hooks for automation and workflow customization. Guides through hook events, configuration, and script creation. Use when user wants to create a hook, automate Claude Code, or asks about hook events.

Use when encountering any bug, test failure, or unexpected behavior, before proposing fixes.

Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, artifacts, posters, or applications (examples include websites, landing pages, dashboards, React components, HTML/CSS layouts, or when styling/beautifying any web UI). Generates creative, polished code and UI design that avoids generic AI aesthetics.

Aplica as cores e tipografia oficiais da marca Anthropic a qualquer artefato que se beneficie da identidade visual da empresa. Use-o quando diretrizes de estilo, formatação visual ou padrões de design da empresa forem aplicáveis.

Constructs and validates polygenic risk scores using LDpred2-auto, SBayesRC, MegaPRS, PRS-CS, PROSPER, MUSSEL, BridgePRS, JointPRS, PRSmix, or PGS Catalog Calculator with ancestry-aware reference panels (HapMap3, UKB-LD), Pejaver-style calibration, and PRS-RS reporting standards. Use when computing PRS for cohorts, applying Whiffin-style absolute-risk transformation, assessing cross-ancestry porta

Create database migrations from model changes, schema diffs, and migration best practices.

Gere imagens de IA com mais de 50 modelos como FLUX, Gemini e Grok via CLI inference.sh. Oferece capacidades como texto-para-imagem, edição de imagem e upscaling, ideal para arte de IA, mockups de produtos e visuais de marketing.

Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix,

Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning archit