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Comprehensive PDF manipulation, extraction, and generation with support for text extraction, form filling, merging, splitting, annotations, and creation. Use when working with .pdf files for: (1) Extracting text and tables, (2) Filling PDF forms, (3) Merging/splitting PDFs, (4) Creating PDFs programmatically, (5) Adding watermarks/annotations, (6) PDF metadata management

Interactive cell type annotation for IMC data. Covers napari-based annotation, marker-guided labeling, training data generation, and annotation validation. Use when manually annotating cell types for training classifiers or validating automated phenotyping results.

Design and implement React Server Components with Next.js 15 App Router. Master server-first architecture, streaming SSR, Server Actions, and modern data fetching patterns for 2025+ frontend development.

Evaluates genome assembly quality across the three orthogonal axes - contiguity (QUAST auN/NG50/NGx, not bare N50), completeness (BUSCO/compleasm gene-space plus Merqury k-mer completeness), and correctness (reference-free Merqury QV, Inspector/CRAQ structural errors, asmgene false-duplication/collapse). Covers why N50 is the most-gamed metric, why QV measured on the polishing reads is circular, d

Use when designing, architecting, or planning a new system from requirements or ideas - transforms concepts into navigable design catalog using EventStorming methodology, Mermaid diagrams, and progressive elaboration through 5 phases (Requirements, Big Picture, Processes, Data/Flows, Integration)

当需要用 lark-cli 操作飞书多维表格（Base）时调用：适用于建表、字段管理、记录读写、视图配置、历史查询，以及角色/表单/仪表盘管理；也适用于把旧的 +table / +field / +record 写法改成当前命令写法。涉及字段设计、公式字段、查找引用、跨表计算、行级派生指标、数据分析需求时也必须使用本 skill。

Predict peptide-MHC class I and II binding affinity using MHCflurry and NetMHCpan neural network models. Identify potential T-cell epitopes from protein sequences. Use when predicting MHC binding for vaccine design or neoantigen identification.

Todo produto será impulsionado por IA. Esta skill ensina a construir produtos de IA corretamente, cobrindo integração de LLM, arquitetura RAG, engenharia de prompt escalável, UX de IA confiável e otimização de custos para evitar falhas em produção.

Load spatial transcriptomics data from Visium, Xenium, MERFISH, Slide-seq, and other platforms using Squidpy and SpatialData. Read Space Ranger outputs, convert formats, and access spatial coordinates. Use when loading Visium, Xenium, MERFISH, or other spatial data.

Monarch Initiative knowledge graph REST API for disease-gene-phenotype associations and cross-species orthology. MONDO disease-to-gene/phenotype, HP phenotype profiles, cross-species comparisons. Use for rare disease gene prioritization and phenotype-based candidate ranking. For GWAS use gwas-database; for clinical pathogenicity use clinvar-database.

Generate videos with Pruna P-Video and WAN models via inference.sh CLI. Models: P-Video, WAN-T2V, WAN-I2V. Capabilities: text-to-video, image-to-video, audio support, 720p/1080p, fast inference. Pruna optimizes models for speed without quality loss. Triggers: pruna video, p-video, pruna ai video, fast video generation, optimized video, wan t2v, wan i2v, economic video generation, cheap video gener

Graph-informed mutation testing triage. Parses codebases with Trailmark, runs mutation testing and necessist, then uses survived mutants, unnecessary test statements, and call graph data to identify false positives, missing test coverage, and fuzzing targets. Use when triaging survived mutants, analyzing mutation testing results, identifying test gaps, finding fuzzing targets from weak tests, runn