Explore skills

Molecular docking: ligand preparation, receptor setup, AutoDock Vina workflow, scoring functions, and binding pose analysis. Use when predicting protein-ligand interactions.

Differentially Methylated Regions (DMRs)

Differential binding analysis for ChIP-seq, covering DiffBind workflow, consensus peaks, normalization, and MA/volcano plots. Useful for comparing ChIP-seq signals across different conditions.

Clinical genomics, covering ACMG/AMP variant classification, ClinVar queries, and clinical reporting workflows.

CITE-seq and Multiome integration, featuring ADT normalization (CLR/DSB), WNN graph construction, and paired RNA+ATAC analysis with muon.

ChIP-seq pipeline covering quality control, alignment, deduplication, peak calling using MACS2, and signal normalization with deepTools.

scRNA-seq cell type annotation includes manual marker scoring, SingleR reference-based methods, and CellTypist automated classification.

Integrative bioinformatics pipeline covering sequence QC, BLAST identification, MSA, phylogenetics, structure analysis, GO enrichment, and publication figures.

LLM fine-tuning with HuggingFace Transformers, covering LoRA math, QLoRA 4-bit NF4 quantization, chat templates, and the SFTTrainer workflow.

Cancer transcriptomics for melanoma subtype classification (Tirosh/Harbst), employing a preprocessing pipeline, PCA/t-SNE, hierarchical clustering, random forest, and Kaplan-Meier survival analysis.

Biochemistry fundamentals for computational biologists, covering Beer-Lambert law, spectrophotometric assays, Michaelis-Menten kinetics, linearization methods, and inhibition models.

A 5-stage escalation framework for legitimate account holders whose recovery has failed through standard platform support. It covers platform legal channels, state Attorneys General, the FTC, congressional offices, and attorney engagement, to be used when a user loses account access due to hijacking, ban, lockout, billing dispute, or impersonation.