Dados e Análise

Query PubChem via PUG-REST API/PubChemPy (110M+ compounds). Search by name/CID/SMILES, retrieve properties, similarity/substructure searches, bioactivity, for cheminformatics.

Acesse dados farmacogenômicos do ClinPGx (sucessor do PharmGKB). Consulte interações gene-medicamento, diretrizes CPIC e funções de alelos para medicina de precisão e decisões de dosagem guiadas por genótipo.

Predict miRNA target genes using sequence-based algorithms and database lookups. Use when identifying potential mRNA targets of differentially expressed or functionally important miRNAs.

Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection

Chave API para as APIs de dados MaxHub. Obtenha uma em https://www.aconfig.cn

Work on the core package (types, validation, normalization, diff). Use when modifying DSL processing logic or data flow.

Build interactive HTML/web visualizations with plotly (Python/R), bokeh (Python), and gganimate/plotly frames for animation, with awareness of current Kaleido static-export model (post-orca-EOL), HTML file-size bloat, and the limits of interactive-only output for journal submission. Use when producing zoomable/hoverable plots for notebook EDA, supplementary HTML, dashboards, or animated time-cours

Implemente estratégias de cache usando @delon/cache, incluindo cache em memória, LocalStorage, SessionStorage ou interceptadores de cache para requisições HTTP. Suporta expiração baseada em TTL, invalidação, agrupamento e armazenamento persistente, otimizando o desempenho ao reduzir chamadas de API e consultas a banco de dados redundantes.

Quality control metrics for ATAC-seq data including fragment size distribution, TSS enrichment, FRiP, and library complexity. Use when assessing ATAC-seq library quality before or after peak calling to identify problematic samples.

Create, manipulate, and convert bedGraph files for genome browser visualization. Covers bedGraph format, conversion to/from bigWig, normalization, and signal processing. Use when handling coverage and signal tracks from ChIP-seq, ATAC-seq, or RNA-seq.

PyTorch Geometric (PyG) for graph neural networks — node/link/graph classification, message passing (GCN, GAT, GraphSAGE, GIN), heterogeneous graphs, neighbor sampling, and custom datasets. Use when working with torch_geometric, not for general NetworkX analytics or non-graph PyTorch models.

Crie migrações de banco de dados reversíveis e focadas com nomenclatura adequada, controle de versão e considerações para implantação sem tempo de inatividade. Use esta skill para alterações de esquema, rollbacks e gerenciamento de controle de versão do banco de dados.