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Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution alon

Senior Risk Management specialist for medical device companies implementing ISO 14971 risk management throughout product lifecycle. Provides risk analysis, risk evaluation, risk control, and post-production information analysis. Use for risk management planning, risk assessments, risk control verification, and risk management file maintenance.

When the user wants to optimize logo placement, linking, or branding on a website. Also use when the user mentions "logo," "brand logo," "header logo," "logo placement," "AI logo design," "logo link," "logo alt text," "logo sizing," "favicon logo," or "logo usage." For full brand visuals, use brand-visual-generator.

AI-powered PPT generation with document analysis and styled images

Launch GStack Browser — AI-controlled Chromium with the sidebar extension baked in. Opens a visible browser window where you can watch every action in real time. The sidebar shows a live activity feed and chat. Anti-bot stealth built in. Use when asked to "open gstack browser", "launch browser", "connect chrome", "open chrome", "real browser", "launch chrome", "side panel", or "control my browser"

Aplica princípios do 'Clean Code' de Robert C. Martin. Use esta skill ao escrever, revisar ou refatorar código para garantir alta qualidade, legibilidade e manutenibilidade, cobrindo nomeação, funções, comentários, tratamento de erros e design de classes.

When a founder needs demo scripts, discovery call frameworks, objection handling, RFP/RFI responses, competitive feature matrices, POC planning, or closing playbooks. Activate for sales calls, demo prep, talk tracks, bid responses, competitor comparisons, or pre-sales engineering.

JPA/Hibernate patterns for entity design, relationships, query optimization, transactions, auditing, indexing, pagination, and pooling in Spring Boot.

When the user wants to create, optimize, or analyze a referral program, affiliate program, or word-of-mouth strategy. Also use when the user mentions 'referral,' 'affiliate,' 'ambassador,' 'word of mouth,' 'viral loop,' 'refer a friend,' 'partner program,' 'referral incentive,' 'how to get referrals,' 'customers referring customers,' or 'affiliate payout.' Use this whenever someone wants existing

Um gêmeo digital conversacional de Nicolau Maquiavel, destilado de suas obras completas. Oferece análise de poder, estruturas de tomada de decisão estratégica e avaliação de riscos no seu estilo realista característico.

Identifies super-enhancers from H3K27ac ChIP-seq data using ROSE and related tools. Use when studying cell identity genes, cancer-associated regulatory elements, or master transcription factor binding regions that cluster into large enhancer domains.

Python framework for single- and multi-objective optimization with evolutionary algorithms. Define vectorized objectives and constraints; solve with NSGA-II, NSGA-III, MOEA/D, GAs, or differential evolution. Analyze Pareto fronts, visualize trade-offs, customize operators and callbacks. For engineering design, hyperparameter search, and conflicting objectives. Alternatives: scipy.optimize (single-