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Python library for working with geospatial vector data including shapefiles, GeoJSON, and GeoPackage files. Use when working with geographic data for spatial analysis, geometric operations, coordinate transformations, spatial joins, overlay operations, choropleth mapping, or any task involving reading/writing/analyzing vector geographic data. Supports PostGIS databases, interactive maps, and integ

Calculate sequence properties like GC content, molecular weight, isoelectric point, and GC skew using Biopython. Use when analyzing sequence composition, computing physical properties, or comparing sequences.

FastAPI web framework patterns. Triggers on: fastapi, api endpoint, dependency injection, pydantic model, openapi, swagger, starlette, async api, rest api, uvicorn.

Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.

Profile and optimize Python code using cProfile, memory profilers, and performance best practices. Use when debugging slow Python code, optimizing bottlenecks, or improving application performance.

Compute evolutionary distances and build phylogenetic trees using Biopython Bio.Phylo.TreeConstruction. Use when creating distance matrices from alignments, building NJ/UPGMA trees, generating bootstrap consensus, or needing quick exploratory phylogenies before running full ML analysis.

Memória persistente de threads para agentes OpenClaw em qualquer plataforma (Moltbook, Hacker News, Reddit, Discord, Twitter). Rastreia threads, exibe apenas novas respostas e um cursor de feed para evitar releituras, ideal para agentes que precisam lembrar quais threads interagiram entre sessões.

Padrões modernos de desenvolvimento de API para serviços web de alto desempenho e escaláveis, abrangendo async/await, REST/GraphQL, middleware, tratamento de erros, limitação de taxa, OpenAPI, testes e otimizações de produção. Estes padrões agnósticos de framework são aplicáveis a Python, Node.js, Go e outras linguagens.

Autenticação com o Azure Identity SDK para Python. Utilize para DefaultAzureCredential, identidade gerenciada, service principals e cache de tokens.

Iterate on the Cardputer-Adv MicroPython app bundle (Claude Buddy, Snake, Hello) after the device is already provisioned via m5-onboard. Use when the user wants to add a new app, push a single changed .py without re-flashing, watch device serial logs, or run a one-shot REPL command. Trigger on "add an app", "push to the cardputer", "tail the device", "run on the device", or follow-up work after /m

Use when implementing JWT authentication in FastAPI or Python projects. Triggers for: token generation, verification middleware, current user extraction, access token creation, token decoding, or role-based auth. NOT for: OAuth2 provider setup, OpenID Connect, or non-Python backends.

Observability patterns for Python backends. Use when adding logging, metrics, tracing, or debugging production issues.