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Load, convert, and manipulate Hi-C contact matrices using cooler format. Read .cool/.mcool files, convert from .hic format, access matrix data, and export to different formats. Use when loading or converting Hi-C contact matrices.

Upgrade Next.js to the latest version following official migration guides and codemods

Parallel/distributed computing. Scale pandas/NumPy beyond memory, parallel DataFrames/Arrays, multi-file processing, task graphs, for larger-than-RAM datasets and parallel workflows.

API key for MaxHub data APIs. Get one at https://www.aconfig.cn

When the user wants to create competitor comparison or alternative pages for SEO and sales enablement. Also use when the user mentions 'alternative page,' 'vs page,' 'competitor comparison,' 'comparison page,' '[Product] vs [Product],' '[Product] alternative,' or 'competitive landing pages.' Covers four formats: singular alternative, plural alternatives, you vs competitor, and competitor vs compet

Validates environment variables, config files, and ensures all required settings are documented. Use when working with .env files, configs, or deployment settings.

Build publication-quality figures in R with ggplot2 using the grammar of graphics (data + aesthetics + geometries + scales + facets + themes) with CVD-safe palettes, cairo_pdf TrueType embedding, programmatic aes via tidy evaluation, and the theme_classic publication baseline. Use when producing static figures in R for papers, presentations, or reports.

Perform differential expression analysis of miRNAs between conditions using DESeq2 or edgeR with small RNA-specific considerations. Use when identifying miRNAs that change between treatment groups, disease states, or developmental stages.

Create Zustand stores with TypeScript, subscribeWithSelector middleware, and proper state/action separation. Use when building React state management, creating global stores, or implementing reactive state patterns with Zustand.

Professional, ethical HR partner for hiring,

分析一段时间内健康数据的趋势和模式。关联药物、症状、生命体征、化验结果和其他健康指标的变化。识别令人担忧的趋势、改善情况，并提供数据驱动的洞察。当用户询问健康趋势、模式、随时间的变化或"我的健康状况有什么变化？"时使用。支持多维度分析（体重/BMI、症状、药物依从性、化验结果、情绪睡眠），相关性分析，变化检测，以及交互式HTML可视化报告（ECharts图表）。

Audits a local Claude-managed knowledge base in Simon's '/Users/simon/Claude CoWork/Knowledge Base/' system. Surfaces contradictions between articles, broken backlinks, unsourced claims, stale articles, writing-rules violations, and three suggested new articles. Files a full report into the KB's 'Outputs/' folder, appends a one-line CHANGELOG entry, and (in interactive sessions) walks through whic