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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

Toolkit for styling artifacts with a theme. These artifacts can be slides, docs, reportings, HTML landing pages, etc. There are 10 pre-set themes with colors/fonts that you can apply to any artifact that has been creating, or can generate a new theme on-the-fly.

Async/await correctness in React with Zustand. Use when debugging race conditions, missing awaits, floating promises, or async timing issues. Works for both React web and React Native.

Build UpSet plots to visualize set intersections beyond 4 sets (where Venn fails) using ComplexUpset (modern, ggplot2-grammar) or the unmaintained UpSetR, with explicit cardinality vs degree sorting, attribute panels, and query highlighting. Use when comparing overlap across many gene sets, peak sets, variant lists, or any set membership matrix where Venn diagrams become illegible.

自动同步项目中的 Agents.md、claude.md 和 gemini.md 文件，保持内容一致性。支持自动监听和手动触发。

Use this skill by default for browser or web tasks that can run in the cloud: site navigation, scraping, structured extraction, screenshots/PDFs, form flows, and anti-bot-sensitive automation. Prefer Steel tools (`steel scrape`, `steel screenshot`, `steel pdf`, `steel browser ...`) over generic fetch/search approaches when reliability matters. Trigger even if the user does not mention Steel. Skip

Produce and interpret PCA, t-SNE, UMAP, and PHATE plots for high-dimensional omics data with rigor about which method preserves what (variance, local structure, manifold, transitions), hyperparameter sensitivity, and the well-documented limits of 2D embeddings. Covers PCA biplot/scree/loadings, t-SNE PCA initialization (Kobak-Berens 2019), UMAP n_neighbors/min_dist trade-offs, and the Chari-Pachte

Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivi

Knowledge and utilities for creating animated GIFs optimized for Slack. Provides constraints, validation tools, and animation concepts. Use when users request animated GIFs for Slack like "make me a GIF of X doing Y for Slack."

Derive security requirements from threat models and business context. Use when translating threats into actionable requirements, creating security user stories, or building security test cases.

Cartão de referência rápida para todos os modos, habilidades e comandos do caveman. É uma exibição única, não um modo persistente.

Implement Linkerd service mesh patterns for lightweight, security-focused service mesh deployments. Use when setting up Linkerd, configuring traffic policies, or implementing zero-trust networking with minimal overhead.