bg-szy

Retrieve records from NCBI databases using Biopython Bio.Entrez (EFetch, ESummary). Use when downloading sequences, fetching GenBank/GenPept records, getting document summaries, parsing nested XML, navigating GI deprecation, choosing between rettype+retmode combinations, and parsing into Biopython SeqRecord/SwissProt objects. Covers nucleotide, protein, gene, pubmed, sra, gds, taxonomy, snp, clinv

Orquestra o desenvolvimento de funcionalidades de backend de ponta a ponta, desde os requisitos até a implantação. Use ao coordenar a entrega de funcionalidades multifásicas entre equipes e serviços.

Create professional research posters in LaTeX using beamerposter, tikzposter, or baposter. Support for conference presentations, academic posters, and scientific communication. Includes layout design, color schemes, multi-column formats, figure integration, and poster-specific best practices for visual communication.

Padrões de arquitetura de backend, design de API, otimização de banco de dados e melhores práticas de servidor para Node.js, Express e rotas de API do Next.js.

Waypoint plans methodology and session survival patterns for Claude Code. Use when working on long-running features, need to resume after context reset, want to document task progress, or need to survive session interruptions. Covers three-file structure (plan/context/tasks), SESSION PROGRESS tracking, quick resume instructions, update frequency, and context handoff patterns.

Apply STRIDE methodology to systematically identify threats. Use when analyzing system security, conducting threat modeling sessions, or creating security documentation.

Design philosophy docs and canvas-based visual creation. Use when articulating design principles, crafting multi-page design documents, or exploring aesthetic philosophy with intentional design thinking.

ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.

Detect signatures of natural selection using Fst, Tajima's D, iHS, XP-EHH, and other selection statistics. Calculate population differentiation, test for departures from neutrality, and identify selective sweeps with scikit-allel and vcftools. Use when computing selection signatures like Fst or Tajima's D.

Orval APIクライアント生成スキル（OpenAPI仕様書から型安全なAPIクライアントを自動生成）

Search the web using Perplexity AI. Use when needing to search, look up, research, find current information, best practices, compare technologies, or answer factual questions about tools and libraries.

Calculate portfolio risk metrics including VaR, CVaR, Sharpe, Sortino, and drawdown analysis. Use when measuring portfolio risk, implementing risk limits, or building risk monitoring systems.